Evaluation of Ablation Lesions Using Cardiovascular Magnetic Resonance Imaging

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Observational
SUMMARY

Ineffective ablation lesions can cause arrhythmia recurrence after catheter ablation for cardiac arrhythmia. Ablation lesions can be created with various ablation energy modalities. This study uses cardiovascular magnetic resonance imaging to evaluate the ablation lesion characteristics of radiofrequency ablation, ultra-low temperature cryo ablation, and pulsed field ablation. The ablation lesion characteristics of different energy characteristics will be compared. Additionally, arrhythmia recurrence and quality of life will be evaluated for the different energy modalities.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:

• Adult patients (age ≥18 years old)

• Paroxysmal or persistent atrial fibrillation, meeting criteria of the 2020 European Society of Cardiology Guidelines for diagnosis and management of atrial fibrillation

• Patients scheduled to undergo catheter ablation for cardiac arrhythmia using one of the following techniques: Radiofrequency ablation (High power, short duration), Ultra-low temperature cryo ablation, or Pulsed field ablation

Locations
Other Locations
Netherlands
St. Antonius Hospital
RECRUITING
Nieuwegein
Contact Information
Primary
Lucas VA Boersma, MD, PhD
l.boersma@antoniusziekenhuis.nl
0883200900
Backup
Bob GS Abeln, MD
b.abeln@antoniusziekenhuis.nl
0883201212
Time Frame
Start Date: 2023-03-08
Estimated Completion Date: 2028-04-01
Participants
Target number of participants: 60
Treatments
Radiofrequency ablation, High power, short duration
Radiofrequency ablation is an ablation modality that uses radiofrequency energy to create ablation lesions through heat. Patients that are scheduled for pulmonary vein isolation using radiofrequency ablation will be consented for study participation.
Ultra-low temperature cryo ablation
Ultra-low temperature cryo ablation is an ablation modality that uses nitrogen near its liquid-vapor critical point to create ablation lesions through ultra-low temperatures. Patients that are scheduled for pulmonary vein isolation using ultra-low temperature cryo ablation will be consented for study participation.
Pulsed field ablation
Pulsed field ablation is an ablation modality that uses short lived electrical fields to create ablation lesions through irreversible electroporation. Patients that are scheduled for pulmonary vein isolation using pulsed field ablation will be consented for study participation.
Related Therapeutic Areas
Sponsors
Leads: R&D Cardiologie

This content was sourced from clinicaltrials.gov